Sildenafil in medicine: research, effectiveness
Sildenafil is a medication that is used to treat erectile dysfunction in men. It belongs to the group of phosphodiesterase type 5 inhibitors (PDE-5).
Mechanism of action
Sildenafil acts by inhibiting the enzyme PDE-5, which destroys cyclic guanosine monophosphate (cGMP). This leads to an increase in the concentration of cGMP in the cavernous body of the penis, which causes relaxation of smooth muscles and increased blood flow. As a result, an erection occurs.
Research
Sildenafil was developed in the 1990s and has undergone numerous clinical trials. In these studies, sildenafil has been shown to be an effective and safe drug for the treatment of erectile dysfunction.
In one study conducted in 2002, sildenafil was shown to be effective in 82% of men with erectile dysfunction. Another study conducted in 2004 showed that sildenafil is safe and well tolerated.
Efficiency
Sildenafil is an effective drug for the treatment of erectile dysfunction. It helps men achieve and maintain an erection sufficient for sexual intercourse.
Sildenafil is not a panacea for all erection problems. It is not suitable for the treatment of other sexual disorders such as premature ejaculation or decreased libido.
Side effects
Sildenafil can cause side effects such as headache, hot flashes, dyspepsia, nasal congestion and visual disturbances. These side effects are usually minor and resolve on their own.
Contraindications
Sildenafil is contraindicated in case of allergy to sildenafil or any of the components of the drug, as well as when taking nitrates or other drugs at the same time that can cause a decrease in blood pressure.
Interaction with other drugs
Sildenafil may interact with other drugs such as nitrates, alpha blockers, and HIV protease inhibitors. Therefore, it is necessary to consult a doctor before taking sildenafil.
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